AWARDEE OF MEDICAL SCIENCES PRIZE

HAN QIDE

Abstract

Han Qide, a member of Chinese Academy of Science, was born in Shanghai on July 19, 1945.  He graduated from the Shanghai First Medical College Faculty of Medicine in 1968 and worked as a clinical doctor in Lintong County, Shaanxi Province in 1969-1979. He got Master of Medicine (Pathophysiology) in Xian Medical College in 1982 and has been working in Beijing Medical University since then.  He worked as a visiting scholar in Department of Pharmacology, Emory University, U.S.A.in 1985-1987 and was invited as a visiting professor at Emory University from 1989 to 1995 (worked for 3 months each year).  Currently he is Professor, vice-president, dean of Graduate School and director of Institute of Cardiovascular Research in Beijing Medical University; director, Key Laboratory of Ministry of Public Health for Peptides and Molecular Cardiovascular Research; Member, Discipline Appraisal Groups of Degree Committee, State Council; vice-chairman, Science and Technology Committee, State Education Commission; Council member, International Society for Heart Research (ISHR); president, Chinese Section, ISHR; Council member, International Society for Pathophysiology; secretary general, Chinese Association of Pathophysiology; Member of Standing Committee, Chinese Society for Pharmacology (CSP); President, Society for Cardiovascular Pharmacology of CSP; Editors for more than ten scientific journals, such as Clinical and Experimental Pharmacology and Physiology, Acta Pharmacologica Sinica, etc.. He has been a standing Committee Member of Chinese People Political Consultative Conference since 1998.
Han Qide has been majoring basic cardiovascular research for a long period and has got important achievement during the past decade. He took the lead in verification of the hypothesis that α1-adrenoceptor (α１-AR) contained two subtypes, α1Ａ and α１Ｂ, by their different pharmacological characteristics, established the approached to distinct these two subtypes, and revealed different signal transduction mechanisms between the two subtypes in smooth muscles. The results were published in Nature, Molecular Pharmacology and other top international journals, and got international recognization. Afterwards, in addition to the further verification of existence of the third subtype (α１Ｄ) and studies on basic characteristics of different subtypes, he mainly focused on distribution, expression, mediated biological function, regulation, cross-talks with β- adrenoceptors, and pathophysiological alterations of different α１-AR subtypes in heart and blood vessels.  The results are of important values in exploring the physiological and pathophysiological significance of existence of the multiple subtypes of α１-AR in heart and blood vessels.  He received the First Class Award of Science and Technology Achievements from the State Education Commission (First Awardee) and the Third Class Award of Natural Science from the State Science and Technology Commission (First Awardee).
Han Qide achieved creative results in study of cardiovascular peptides as well.  He was first to report some cardiovascular effects of neuropeptide Y, and revealed that the increase of neuropeptide Y in cerebrospinal fluid played a key role in the cerebral vascular spasm during late stage of subarachnoid hemorrhage. The research on neuropeptide Y received the Third Class Award of Science and Technology achievements from Ministry of Public Health (First Awardee).  He recently approved that neuropeptide Y was not only existed in nerve endings, but also in blood platelets, which played an important role in pathogenesis of hypertension.  Besides, collaborated with colleagues, he took leads to raise the hypothesis that calcitonin gene-related peptide was a common messager molecule between neurons and immune systems, which received the Second Class Award of Science and Technology Achievements from State Education Commission (Second Awardee).
In the past 10 years, he has published over 200 scientific papers, among which over 40 papers were published in international journals.  The papers have been cited more than 1400 times by SCI searched journals.  Only the paper published in Nature has been cited over 440 times.